Heavy Rain, although not necessarily the best game, is definitely in the running for most innovative.Mass Effect 2 was a great game. It would definitely be a contender for one of this year's best.
Heavy Rain was alright. I don't regret buying it for I liked its story but its numerous plot holes and the fact that it is more of an interactive movie than anything else sort of works against it for me.
FFXIII is also a contender but probably won't win. It seems everyone is really against the fact it is so linear? I'll play it for myself this week and find out personally.