"explain the relationship between the structure and behaviour of chromosomes during meiosis and the inheritance of genes"
My suggested short essay response to his question is:
“During meiosis, cells, which have already undergone DNA replication during Interphase, to double their DNA content producing sister chromatids, enter two rounds of division to produce four unique haploid cells, with only half the DNA of the original cell.
The two meiotic divisions are known as meiosis I and meiosis II. In each round of division, cells go through four stages: Prophase, Metaphase, Anaphase and Telophase. In meiosis I, separation of homologous (similar but non identical) pairs of chromosomes occurs, whilst in meiosis II, separation is of homologous pairs of sister chromatids.
Meiosis I
In Prophase I, the chromosomes condense and the pairs align so that genetic material from the paternal and maternal copies of each pair of chromosome are able to cross over. The DNA breaks at the same spots on each homologue (more or less randomly) and reconnect in a criss-cross structure. This link is stabilised by proteins and the structure, called a chiasma, holds the homologues together, so that they can exchange part of their DNA in a process called crossing over, creating new and unique DNA combinations in each chromosome.
After crossing over, in Metaphase I, cytoskeletal structures called spindles form by assembly of microtubules and capture chromosomes to move them towards the center of the cell. Each chromosome attaches to microtubules from only one pole of the spindle and the homologues of each pair of chromosomes bind to opposite poles when they line up at the metaphase plate for separation.
In Anaphase I, homologues separate to opposite ends of the cell, with sister chromatids of each chromosome staying together (but they are no longer identical due to the crossing over in Prophase I). Finally, in Telophase I, the chromosomes arrive at opposite poles of the cell and prepare for another round of division - meiosis II
Cells move on from meiosis I to meiosis II without copying their DNA.
Meiosis II is a similar process to meiosis I, but instead of separating chromosomes, sister chromatids separate to produce haploid cells.
Meiosis II
The cells that enter meiosis II are the ones produced in meiosis I.
In Prophase II, chromosomes condense. They line up at the metaphase plate in Metaphase II, with each chromatid of the sister pair attaching itself to opposite poles of the spindle. In Anaphase II, sister chromatids separate to opposite ends of the cell.
In Telophase II, nuclear membranes form around each newly formed haploid set of chromosomes and the chromosomes decondense. Each chromosome now has just one chromatid.
Since there have been TWO rounds of division, with each round halving DNA content and only ONE round of replication prior to meiosis, each of these four gamete cells contains only half the genetic material of the original cell, and because of the crossing over in Prophase I, each gamete cell is unique. Gamete cells form ovum in females and sperm in males and the combination of two unique gametes produces a zygote which, through this process of genetic inheritance, becomes a unique individual organism which has the same number of chromosomes and same amount of DNA as each of its parents.”
Note:
I’ve described meiosis II for completeness, but depending on time in an exam and the marks allocated to the question, the entire paragraph on meiosis II really could be left out without loss of information as long as the preceding sentence “Meiosis II is a similar process to meiosis I, but instead of separating chromosomes, sister chromatids separate to produce haploid cells” is included.
I have nothing to do with HSC exams, but I have marked postgrad exam papers, so my general tip is that questions are worded to elicit responses which show that students understand the topic and aren’t just regurgitating generic notes. Therefore, in an exam situation, don’t waste precious time on details which won’t gain marks.
For this question, don’t waste time explaining differences between mitosis & meiosis, nor on the number of chromosomes in different organisms, nor autosomal recessive and autosomal dominant patterns of gene inheritance. It is highly unlikely that any marks would be awarded for any of these details.
With this particular question, the tricky bit is deciding whether to include the DNA replication process which technically occurs prior to (not during) meiosis. This process prior to meiosis is relevant to inheritance of genes so I would include but would ensure that it is clear (to the examiner) that it was understood what occurs prior to and what occurs during meiosis.
Hope this is useful.