Firstly, just consider the asymptotes of the hyperbola x^2/64-y^2/36=1. This would just be y = ±3x/4. Now, to find the asymptotes of (x-3)^2/64 - (y+1)^2/36 = 1, notice that it is just the hyperbola x^2/64-y^2/36=1 but translated 3 to the right and 1 down. So just replace x with x-3 and y with y+1 to get the asymptotes as y+1=±3(x-3)/4 or y = 3x/4 - 13/4 and y = -3x/4 + 5/4.